Archive for February, 2008

Dr.Duvall introduces the melatonin.

Friday, February 29th, 2008

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Exogenous melatonin, usually taken orally in the afternoon or evening, is, together with light therapy upon awakening, the standard treatment for delayed sleep phase syndrome and non-24-hour sleep-wake syndrome. See Phase response curve, PRC. It appears to have some use against other circadian rhythm sleep disorders, such as jet lag and the problems of people who work rotating or night shifts.

Just what is it that makes us sleep? What a great question! So if only researchers could pinpoint the answer then perhaps all the companies that manufacturer insomnia medications would be out of business.

It really doesn’t matter to whom you ask what it is that makes us sleep, but one thing is for sure and that is you will get a range of answers.

While there are some of us who must have a comfortable bed and a quiet bedroom, there are others who simply believe that the body will sleep when you are tired enough and actually in need of sleep. Many people would say that a big, fat, hearty meal would cause you to sleep. But guess what folks, the actual answer to this question is that you sleep when the natural hormone melatonin is released.

The hormone melatonin is secreted from a gland located at the base of the brain called the pineal gland. Melatonin is secreted at various levels all day long. The varying levels of melatonin which are present in your body at any given time helps your body to regulate your body’s natural sleep-wake cycle. So think about it, the tiny pineal gland is responsible for your night of restful sleep or lack thereof. The pineal gland and the melatonin it secretes helps to regulate your internal body clock, which then helps to keep the body in a state of chemical balance that impact the body in many different ways.

For example, there is a correlation between the release of melatonin and the body’s temperature, both of which are controlled by the body’s circadian rhythm. Melatonin levels and your body’s temperature are both actually lower during the daytime but they gradually increase as evening approaches and as you might have suspected, your body’s temperature and melatonin levels reaching their highest levels during nighttime sleeping which makes the most sense.

The pineal gland is stimulated by sunset and darkness which is you’re your melatonin levels increase as darkness falls. But the opposite is true during the daytime hours, which is when you will find that your melatonin levels are barely traceable. But, as daytime turns into night, the pineal gland begins to release additional melatonin into the bloodstream. You can almost feel the sleepiness creeping in as your melatonin level increases. By this time your eyelids should be feeling heavy and your body should feel tired. Another thing that happens as your body gets ready for sleep is to actually lower your blood pressure. This process continues as the melatonin in your bloodstream continues to increase until it peaks in the wee hours of the morning around 3 or 4 AM. And then you must realize what a miraculous thing your body is, since as the levels peak, they then begin to decline which helps you to being to wake up.

Of course, anything that disrupts the normal release cycle of melatonin can also disrupt your sleep patterns. If your body senses lower levels of melatonin then your body will begin to wake you up and prepare for the daytime.

So, although it is probably not the thing you obsess over, knowing what triggers the sleep cycle is an important piece of knowledge which can help you get a restful night’s sleep. Melatonin definitely plays a critical role in helping you to consistently enjoy a restful night’s sleep. So supplementing with melatonin might be something to consider if you are fighting insomnia. Talk with your physician to see if this might be something that could be helpful to you.

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Drive with vytorin!

Friday, February 29th, 2008

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YARDLEY, Pa. — For the first time since its launch, the combination drug Vytorin led the cholesterol reducer market in projected switch/add patient transactions for the week ending Jan. 14, according to Verispan’s Vector One(TM): National. Vytorin captured 21.4% of the switches, or 19,355 patient transactions, that occurred during the week.

Vector One: National provides weekly Instant View reports 5 days post-period and monthly reports 10 to 14 days post-period. Vector One’s True Patient Measures utilize de-identified patient records to uniquely pinpoint projected new patient starts, product switches and additions, continuing patients, and a host of other powerful metrics at the individual prescriber level.

According to Vector One: National, Vytorin’s share of prescriptions in its market increased from Medics advise vytorin to byu here.
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Friday, February 29th, 2008

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GlaxoSmithKline has halted its study of Serevent after finding a greater risk of health problems among black patients and a disparity in deaths among those not using a …

(salmeterol xinafoate inhalation powder, GlaxoSmithKline)

A long-acting [beta]-agonist, approved for maintenance treatment of bronchospasm associated with chronic obstructive pulmonary disease (COPD), including emphysema and chronic bronchitis. Previously approved for treating asthma and preventing exercise-induced bronchospasm. This is a dry powder formulation of Serevent (salmeterol), which was approved for the same indication in 1998 as a metered-dose inhaler and is being phased out because it contains ozone-depleting chlorofluorocarbons (CFCs).

* Recommended Dosage: One inhalation (50 [micro]g each) twice a day, every 12 hours.

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Thursday, February 28th, 2008

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According to David Wong,[3] the work which eventually led to the discovery of fluoxetine began at Eli Lilly in 1970 as a collaboration between Bryan Molloy and Robert Rathburn. It was known at that time that antihistamine diphenhydramine shows some antidepressant-like properties. 3-Phenoxy-3-phenylpropylamine, a compound structurally similar to diphenhydramine, was taken as a starting point, and Molloy synthesized dozens of its derivatives. Testing the physiological effects of these compounds in mice resulted in nisoxetine, a selective norepinephrine reuptake inhibitor currently widely used in biochemical experiments.[3]
Later, hoping to find a derivative inhibiting only serotonin reuptake, Wong proposed to re-test the series for the in-vitro reuptake of serotonin, norepinephrine and dopamine. This test, carried out by Jong-Sir Horng in May 1972,[3] showed the compound later named fluoxetine to be the most potent and selective inhibitor of serotonin reuptake of the series.[4]
A controversy ensued after Lilly researchers published a paper entitled “Prozac (fluoxetine, Lilly 110140), the first selective serotonin uptake inhibitor and an antidepressant drug”[3] implicitly claiming fluoxetine to be the first selective serotonin reuptake inhibitor (SSRI). Two years later they had to issue a correction, admitting that the first SSRI was zimelidine developed by Arvid Carlsson and colleagues.[5] Fluoxetine made its appearance on the Belgian market in 1986[6] and was approved for use by the FDA in the United States in December 1987.[7] Fluoxetine was the fourth SSRI to make it to market, after indalpine, zimelidine and fluvoxamine. However, the first two were withdrawn due to the side effects, and a vigorous marketing campaign by Eli Lilly made sure that in the popular culture fluoxetine has been perceived as a scientific breakthrough and associated with the title of the first SSRI.
Eli Lilly’s patent on Prozac (fluoxetine) expired in August, 2001,[8] prompting an influx of generic drugs onto the market.

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Thursday, February 28th, 2008

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Because of the sedative effects of Mirtazapine, excessive sedation may result when it is used with other sedating substances, such as alcohol or benzodiazepines. According to official prescribing information from Organon, mirtazapine should not be used within 14 days of the use of an MAOI because of the risk of serious effects such as hypertensive emergency and hyperthermia.

M2 PRESSWIRE-21 October 2004-MARYLAND ATTORNEY GENERAL: Attorney General Curran announces Remeron settlement for consumers(C)1994-2004 M2 COMMUNICATIONS LTD RDATE:10212004 Attorney General J. Joseph Curran Jr. today announced completion of a proposed $36 million nationwide settlement for consumers, state purchasers, and other indirect purchasers with drug maker Organon USA Inc.

Organon Inc., received Food and Drug Administration approval to market REMERONSolTab (mirtazapine) Orally Disintegrating Tablet. The new …

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Thursday, February 28th, 2008

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Barr Laboratories is seeking to intervene in Zeneca Inc.’s federal lawsuit that charges Eli Lilly with promoting Evista for reducing the risk of breast cancer. Barr’s motion to have full status as a plaintiff-intervenor in the case was filed in U.S. District Court for the Southern District of New York. In February, Zeneca filed a federal suit charging Lilly with false and misleading promotion of Evista for breast cancer, when it has been approved only for prevention of osteoporosis. Nolvadex (Tamoxifen Citrate), which was patented by Zeneca, is the only drug proven effective for that indication.

Women in the U.S. take raloxifene (sold as Evista by Eli Lilly) to treat and prevent osteoporosis. Because raloxifene is also known to lower cholesterol levels, it was hoped that it would also counteract heart problems. However, there are mixed results from a 5-1/2 year study, reported in The New England Journal of Medicine, of more than 10,000 post-menopausal women who had heart disease or were at high risk for it.

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Learning to use the femara.

Wednesday, February 27th, 2008

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Note to Editors:

In the news release “Femara® Demonstrated Early Survival Advantage Over Tamoxifen in Advanced Breast Cancer As Reported in Journal of Clinical Oncology” issued May 29, 2003, the first paragraph, last sentence in the “Clinical Data” section should read “The median overall survival for Femara was 34 months vs. 30 months for tamoxifen (P=0.53).”

The third paragraph, first sentence in the “Clinical Data” section should read, “At the end of the trial (median follow-up of 32 months), 48 patients (11%) receiving first-line Femara remained free of tumor progression, compared with 27 patients (6%) receiving first-line tamoxifen.”

Complete corrected text follows:

Femara(R) Demonstrated Early Survival Advantage Over Tamoxifen in Advanced Breast Cancer as Reported in Journal of Clinical Oncology

Femara First and Only Aromatase Inhibitor to Show Significant Early Survival Advantage Over Tamoxifen

EAST HANOVER, NJ — The largest study ever to evaluate a hormonal therapy in advanced breast cancer demonstrated that Femara® (letrozole tablets) showed superior time to disease proLearning to use the femara.
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Where are all superman?

Wednesday, February 27th, 2008

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Super heroes have never failed to capture the attention and inspire the imagination of people. No age is immune to the appeal that super heroes have. Perhaps the most popular and most loved super hero is the Man of Steel himself. Born out of the Great Depression, the Great White Plains drought, and World War II, Superman is considered to be the greatest hero of all time. Created in 1938 by Jerry Siegel and Joe Shuster, Superman became the “champion of the oppressed.” People of those times were truly able to connect with the idea of someone who would lift them out of their misery. Thus, a legend was born.

Over the decades, Superman’s popularity just continued to rise. More and more comic books were written. TV shows, cartoons, movies, and all sorts of merchandise were produced. As a testament to the pervasiveness of the Superman culture, even technology has not escaped.

With the advent of text messaging and multimedia cell phones, various options for cell phones have become very popular. Ringtones are perhaps the most sought for add-ons to cell phones. Anyone who has had a multimedia cell phone probably has used a Superman ringtone at least once. Different Superman series and movies have different music themes. Some of the most popular Superman ringtones are: “The Adventures of Superman” 1950 TV series, “Superman: The Movie” Theme, “Lois and Clark” TV Theme, “Super Friends” TV Theme, “Superman: The Animated Series” TV Theme, and “Superman: It’s Not Easy” by Five for Fighting. From “Superman: The Movie,” the “Krypton Theme” and the “Love Theme” are quite popular as well. You can find most of these as ringtones and download them to your phone.

In addition to all these exclusively Superman themes, you can also find ringtones from other cartoon series with Superman in them. Justice League has become a very popular cartoon series with all the super heroes put together. You are also sure to find ringtones from the Justice League.

Of course there are different types of ringtones. You can have your pick – monotones, polyphonic tones, real tones. Superman sounds need not be confined to ringtones. Different cell phone functions can be accompanied by different sounds, much like with the computer. You can download such sound effects for your cell phone and enjoy hearing them anytime you use your phone.

More than sounds, cell phones satisfy the sight as well. Feast your eyes on various Superman pictures and scenes and set them as your wallpaper. Some phones allow operator logos. You can opt to download a Superman operator logo.

Of course, if you are really that much of a Superman fan, then the best thing for you to do is download a whole Superman Theme for your cell phone. With the Superman Theme, you get everything you want in one whole package.Ringtones and sound effects are all incorporated within the theme. Your wallpaper and screen savers are also included. More so you can get all sorts of Superman graphics for your cell phone. Icons and color schemes related to anything Superman will surely satisfy your super hero craving.

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Wednesday, February 27th, 2008

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SOMA Networks, Inc., and Motorola Computer Group, a part of Motorola, Inc. (NYSE: MOT), today announced SOMA Networks has chosen the new XIP68 CompactPCI single-board computer for use in the SOMA™ macro base station. The XIP68, with its increased processing power and memory, contributes to improved economics for the SOMA solution due to its increased system capacity and advanced application features. Motorola will supply the XIP68 CompactPCI single-board computer as SOMA Networks scales up production for large-scale commercial deployments of its innovative all-IP, fully converged, end-to-end broadband wireless solution, which cost-effectively delivers high-speed Internet access and landline-quality voice services to the residential and small office market.

The SOMA macro base station is the network infrastructure component of the SOMA solution, which also includes the SOMAport™ subscriber terminal and the SOMA SoftAir™ platform. The SOMA macro base station works in tandem with the advanced SoftAir platform to create a next-generation wireless IP service node that communicates with intelligent subscriber terminals to provide broadband data, landline-quality voice and other advanced applications. A single SOMA macro base station can support thousands of subscribers receiving megabit per second data rates.

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Tuesday, February 26th, 2008

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Cymbalta and thioridazine should not be co-administered.

All adult and pediatric patients being treated with duloxetine for any indication should be observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially when decreasing the dose.[21]

Cymbalta has been found safe and well-tolerated as a drug treatment for diabetic nerve pain. The study in the Journal of Palliative Medicine also concludes …

Business Editors, Health & Medical Writers

INDIANAPOLIS–(BUSINESS WIRE)–Oct. 29, 2002

Data presented showed that depressed patients taking Cymbalta(TM) 60mg once a day had significantly greater improvement in mood and anxiety measures than did placebo treated patients by the end of the first week of therapy. This same data indicated that the improvements seen by week one were also sustained throughout the studies. Other findings presented from an open label trial showed that 79 percent of patients achieved response and 69 percent of patients achieved remission of their symptoms after a year of therapy with either 80 mg/day or 120 mg/day of Cymbalta. Additionally, data from the one-year trial indicated Cymbalta to be relatively well tolerated and safe over long-term treatment. The data were shared at the 15th Annual U.S. Psychiatric and Mental Health Congress in Las Vegas.

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